Controversies of renin–angiotensin system inhibition during the COVID-19 pandemic
Identifieur interne : 000593 ( 2020/Analysis ); précédent : 000592; suivant : 000594Controversies of renin–angiotensin system inhibition during the COVID-19 pandemic
Auteurs : Andrew M. South [États-Unis] ; Laurie Tomlinson [Royaume-Uni] ; Daniel Edmonston [États-Unis] ; Swapnil Hiremath ; Matthew A. Sparks [États-Unis]Source :
- Nature Reviews. Nephrology [ 1759-5061 ] ; 2020.
Abstract
The current COVID-19 pandemic is associated with unprecedented morbidity and mortality. Early reports suggested an association between disease severity and hypertension but did not account for sources of confounding. However, the responsible virus — SARS-CoV-2 — gains entry to host cells via angiotensin-converting enzyme 2 (ACE2), highlighting the need to understand the relationship between the virus and the renin–angiotensin system (RAS) and how this might be affected by RAS inhibitors.
Url:
DOI: 10.1038/s41581-020-0279-4
PubMed: 32246101
PubMed Central: 7118703
Affiliations:
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PMC:7118703Le document en format XML
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South</name><affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2185 3318</institution-id><institution-id institution-id-type="GRID">grid.241167.7</institution-id><institution>Section of Nephrology, Department of Pediatrics,</institution><institution>Wake Forest School of Medicine and Brenner Children’s Hospital,</institution></institution-wrap>Winston Salem, NC USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Winston Salem</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2185 3318</institution-id><institution-id institution-id-type="GRID">grid.241167.7</institution-id><institution>Department of Epidemiology and Prevention, Division of Public Health Sciences,</institution><institution>Wake Forest School of Medicine,</institution></institution-wrap>Winston Salem, NC USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Winston Salem</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2185 3318</institution-id><institution-id institution-id-type="GRID">grid.241167.7</institution-id><institution>Department of Surgery-Hypertension and Vascular Research,</institution><institution>Wake Forest School of Medicine,</institution></institution-wrap>Winston Salem, NC USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Winston Salem</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2185 3318</institution-id><institution-id institution-id-type="GRID">grid.241167.7</institution-id><institution>Cardiovascular Sciences Center,</institution><institution>Wake Forest School of Medicine,</institution></institution-wrap>Winston Salem, NC USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Winston Salem</wicri:cityArea></affiliation></author><author><name sortKey="Tomlinson, Laurie" sort="Tomlinson, Laurie" uniqKey="Tomlinson L" first="Laurie" last="Tomlinson">Laurie Tomlinson</name><affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0425 469X</institution-id><institution-id institution-id-type="GRID">grid.8991.9</institution-id><institution>Department of Non-Communicable Disease Epidemiology,</institution><institution>London School of Hygiene and Tropical Medicine,</institution></institution-wrap>London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>London</wicri:regionArea></affiliation></author><author><name sortKey="Edmonston, Daniel" sort="Edmonston, Daniel" uniqKey="Edmonston D" first="Daniel" last="Edmonston">Daniel Edmonston</name><affiliation wicri:level="2"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7961</institution-id><institution-id institution-id-type="GRID">grid.26009.3d</institution-id><institution>Division of Nephrology, Department of Medicine,</institution><institution>Duke University School of Medicine and Renal Section, Durham VA Health Care System,</institution></institution-wrap>Durham, NC USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Durham</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7961</institution-id><institution-id institution-id-type="GRID">grid.26009.3d</institution-id><institution>Duke Clinical Research Institute,</institution></institution-wrap>Durham, NC USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Durham</wicri:cityArea></affiliation></author><author><name sortKey="Hiremath, Swapnil" sort="Hiremath, Swapnil" uniqKey="Hiremath S" first="Swapnil" last="Hiremath">Swapnil Hiremath</name><affiliation><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2182 2255</institution-id><institution-id institution-id-type="GRID">grid.28046.38</institution-id><institution>Division of Nephrology, Department of Medicine,</institution><institution>University of Ottawa,</institution></institution-wrap>Ottawa, Ontario Canada</nlm:aff><wicri:noCountry code="subfield">Ontario Canada</wicri:noCountry></affiliation></author><author><name sortKey="Sparks, Matthew A" sort="Sparks, Matthew A" uniqKey="Sparks M" first="Matthew A." last="Sparks">Matthew A. Sparks</name><affiliation wicri:level="2"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7961</institution-id><institution-id institution-id-type="GRID">grid.26009.3d</institution-id><institution>Division of Nephrology, Department of Medicine,</institution><institution>Duke University School of Medicine and Renal Section, Durham VA Health Care System,</institution></institution-wrap>Durham, NC USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Durham</wicri:cityArea></affiliation></author></analytic><series><title level="j">Nature Reviews. Nephrology</title><idno type="ISSN">1759-5061</idno><idno type="eISSN">1759-507X</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">The current COVID-19 pandemic is associated with unprecedented morbidity and mortality. Early reports suggested an association between disease severity and hypertension but did not account for sources of confounding. However, the responsible virus — SARS-CoV-2 — gains entry to host cells via angiotensin-converting enzyme 2 (ACE2), highlighting the need to understand the relationship between the virus and the renin–angiotensin system (RAS) and how this might be affected by RAS inhibitors.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zhou, F" uniqKey="Zhou F">F Zhou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hoffmann, M" uniqKey="Hoffmann M">M Hoffmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="South, Am" uniqKey="South A">AM South</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sparks, Ma" uniqKey="Sparks M">MA Sparks</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuba, K" uniqKey="Kuba K">K Kuba</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ferrario, Cm" uniqKey="Ferrario C">CM Ferrario</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Soler, Mj" uniqKey="Soler M">MJ Soler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Burrell, Lm" uniqKey="Burrell L">LM Burrell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ramchand, J" uniqKey="Ramchand J">J Ramchand</name></author></analytic></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Caroline du Nord</li></region></list><tree><noCountry><name sortKey="Hiremath, Swapnil" sort="Hiremath, Swapnil" uniqKey="Hiremath S" first="Swapnil" last="Hiremath">Swapnil Hiremath</name></noCountry><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="South, Andrew M" sort="South, Andrew M" uniqKey="South A" first="Andrew M." last="South">Andrew M. South</name></region><name sortKey="Edmonston, Daniel" sort="Edmonston, Daniel" uniqKey="Edmonston D" first="Daniel" last="Edmonston">Daniel Edmonston</name><name sortKey="Edmonston, Daniel" sort="Edmonston, Daniel" uniqKey="Edmonston D" first="Daniel" last="Edmonston">Daniel Edmonston</name><name sortKey="South, Andrew M" sort="South, Andrew M" uniqKey="South A" first="Andrew M." last="South">Andrew M. South</name><name sortKey="South, Andrew M" sort="South, Andrew M" uniqKey="South A" first="Andrew M." last="South">Andrew M. South</name><name sortKey="South, Andrew M" sort="South, Andrew M" uniqKey="South A" first="Andrew M." last="South">Andrew M. South</name><name sortKey="Sparks, Matthew A" sort="Sparks, Matthew A" uniqKey="Sparks M" first="Matthew A." last="Sparks">Matthew A. Sparks</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Tomlinson, Laurie" sort="Tomlinson, Laurie" uniqKey="Tomlinson L" first="Laurie" last="Tomlinson">Laurie Tomlinson</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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